期刊
MOLECULES
卷 19, 期 9, 页码 13093-13103出版社
MDPI
DOI: 10.3390/molecules190913093
关键词
coumarin; solvent-free; FeF3; one-pot; microwave irradiation; antimicrobial activities
资金
- Research Council of Tonekabon Branch Islamic Azad University
A rapid and efficient solvent-free one-pot synthesis of coumarin derivatives by Pechmann condensation reactions of phenols with ethyl acetoacetate using FeF3 as a catalyst under microwave irradiation is described. This one-pot synthesis on a solid inorganic support provides the products in good yields. The newly synthesized compounds were systematically characterized by IR, H-1-NMR, C-13-NMR, MS and elemental CHN analyses. The proposed solvent-free microwave irradiation method using the environmentally friendly catalyst FeF3 offers the unique advantages of high yields, shorter reaction times, easy and quick isolation of the products, excellent chemoselectivity, and a one-pot, green synthesis. The products were screened for antimicrobial activity, and the results showed that the compounds reacted against all the tested bacteria.
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