期刊
MOLECULES
卷 19, 期 7, 页码 9736-9759出版社
MDPI
DOI: 10.3390/molecules19079736
关键词
flow chemistry; hydrogenation; riboflavine; benzodiazepine; micro reactor
资金
- Royal Society
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.
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