期刊
MOLECULES
卷 19, 期 12, 页码 19350-19360出版社
MDPI
DOI: 10.3390/molecules191219350
关键词
supercritical fluid extraction; response surface methodology; oil; Gardenia jasminoides; antidepressant effect
资金
- Foundation for Science of Chinese Medicine
- Foundation for Science of Integrated Chinese and Western Medicine
- National Natural Science Foundation of China [81403041]
- Natural Science Foundation of Jiangsu Province [BK20140961, BK20140962]
- Natural Science Foundation of Nanjing University of Chinese Medicine [13XZR06]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
A response surface methodology was applied to optimize the variables affecting the supercritical fluid carbon dioxide extraction of oil from the fruit of Gardenia jasminoides using the Box-Behnken design. The optimum extraction parameters were an extraction temperature of 49.94 degrees C, an extraction pressure of 29.89 MPa and an extraction time of 93.82 min. Through a GC/MS analysis, we revealed 16 major components of the oil extract, which showed potent antidepressant effects in both of two behavior despair models in mice: tail suspension test and forced swimming test. Our results suggest that the oil extract of Gardenia jasminoides prepared using the supercritical fluid carbon dioxide extraction may contain effective constituents to be used for depression therapy.
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