Two New Coumarins from Talaromyces flavus

Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher's method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh-2(OCOCF3)(4)] complex. Compounds 1 and 2 were evaluated for their anti-A beta(42) aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-A beta(42) aggregation activity, and this is the first report on the A beta(42) inhibitory aggregation activity of coumarins.