期刊
MOLECULES
卷 19, 期 4, 页码 4313-4325出版社
MDPI
DOI: 10.3390/molecules19044313
关键词
nucleoside phosphonates; extended uridine; P2Y(2) receptor
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y(2) receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties with a suitable ribofuranosephosphonate afforded the desired analogues after full deprotection. In contrast to the parent 5-(4-fluoropheny)uridine phosphonate, the present extended-base uridine phosphonates essentially failed to modulate the P2Y(2) receptor.
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