期刊
MOLECULES
卷 18, 期 11, 页码 13425-13433出版社
MDPI
DOI: 10.3390/molecules181113425
关键词
heterocycles; multicomponent; chemoenzymatic; catalysis; thiazole
资金
- National Natural Science Foundation of China [21106026]
- Key Sci-tech Innovation Team of Zhejiang Province [2010R50017-7]
- PCSIRT [IRT 1231]
A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.
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