期刊
MOLECULES
卷 18, 期 2, 页码 1826-1843出版社
MDPI
DOI: 10.3390/molecules18021826
关键词
evodiamine; bioactivity; mechanism; receptor binding
资金
- National Basic Research Program of China [2012CB518102]
- National Natural Science Foundation of China [81260478, 81171801, 81201497]
- Natural Science Foundation of Inner Mongolia Autonomous Region, China [2011BS1201]
- Chongqing Science and Technology Committee [CSTC2012jjA0171]
- Project of State Key Laboratory of Trauma, Burns, and Combined Injury [SKLKF201205, SKLZZ201108]
- Project of State Key Laboratory of Natural and Biomimetic Drugs [K20120205]
- Science and Technology Support Program of Baotou [2012S2006-04-09]
Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and themoregulative effects. Evodiamine has evolved a superior ability to bind various proteins, so we also argue that it is good starting point for multi-target drugs. This review is primarily addressed to the description of the recent advances in the biological activity studies of evodiamine, with a focus on pharmacological mechanism. The present review also includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design.
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