期刊
MOLECULES
卷 18, 期 6, 页码 7058-7070出版社
MDPI
DOI: 10.3390/molecules18067058
关键词
antimicrobial peptides; dermaseptins; phylloseptins; Phyllomedusa; Leishmania
资金
- CNPq/FAPEPI
- CNPq [476700/2009-4]
- Consolidacao Novos Campi [501874/2009-7]
- Projetos Conjuntos de Pesquisa Cientifica, Tecnologica e de Inovacao/Portugal - CNPq/FCT [490585/2010-8]
Antimicrobial peptides (AMPs) from the dermaseptin and phylloseptin families were isolated from the skin secretion of Phyllomedusa nordestina, a recently described amphibian species from Northeastern Brazil. One dermaseptin and three phylloseptins were chosen for solid phase peptide synthesis. The antiprotozoal and antimicrobial activities of the synthetic peptides were determined, as well as their cytotoxicity in mouse peritoneal cells. AMPs are being considered as frameworks for the development of novel drugs inspired by their mechanism of action.
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