期刊
MOLECULES
卷 18, 期 8, 页码 8994-9009出版社
MDPI
DOI: 10.3390/molecules18088994
关键词
Phoebe grandis; Lauraceae; aporphine alkaloid; cytotoxic; antibacterial
资金
- University of Malaya [PV091/2011B]
- Ministry of Higher Education for the High Impact Research grant [UM-MOHE UM.C/625/1/HIR/MOHE/SC/09]
The oxoaporphine alkaloid lysicamine (1), and three proaporphine alkaloids, litsericinone (2), 8,9,11,12-tetrahydromecambrine (3) and hexahydromecambrine A (4) were isolated from the leaves of Phoebe grandis (Nees) Merr. (Lauraceae). Compounds 2 and 3 were first time isolated as new naturally occurring compounds from plants. The NMR data for the compounds 2-4 have never been reported so far. Compounds 1 and 2 showed significant cytotoxic activity against a MCF7 (human estrogen receptor (ER+) positive breast cancer) cell line with IC50 values of 26 and 60 mu g/mL, respectively. Furthermore, in vitro cytotoxic activity against HepG2 (human liver cancer) cell line was evaluated for compounds 1-4 with IC50 values of 27, 14, 81 and 20 mu g/mL, respectively. Lysicamine (1) displayed strong antibacterial activity against Bacillus subtilis (B145), Staphylococcus aureus (S1434) and Staphylococus epidermidis (a clinically isolated strain) with inhibition zones of 15.50 +/- 0.57, 13.33 +/- 0.57 and 12.00 +/- 0.00 mm, respectively. However, none of the tested pathogenic bacteria were susceptible towards compounds 2 and 3.
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