期刊
MOLECULES
卷 18, 期 2, 页码 1693-1703出版社
MDPI AG
DOI: 10.3390/molecules18021693
关键词
Alzheimer's; free radical injury; polypheols; hydroxyl-substituted chalcones
资金
- Guangdong province Natural Science Foundation of China [10151503102000048]
- Guangdong Natural Science Foundation of China [9351503102000001]
- Doctoral Fund of Ministry of Education of China [20104402120006]
- Science and Technology Planning Project of Guangdong Province in China [2010B030700043]
Alzheimer's disease (AD) pathogenesis involves an imbalance between free radical formation and destruction. In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free radical activity, and screened their effects on scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Compound C7, 4,2'-dihydroxy-3,5-dimethoxychalcone was found to have potent activity in these anti-free radical activity tests. Further research revealed that C7 could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in vivo in the Alzheimer's model. The indication of C7's effect on AD needs further study.
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