期刊
MOLECULES
卷 18, 期 10, 页码 12290-12312出版社
MDPI
DOI: 10.3390/molecules181012290
关键词
2-furylcarbinols; pentadienyl cation; prostaglandins; spirocycles; domino reaction
Nearly forty years ago, at the University of Rome, Giovanni Piancatelli and co-workers discovered the acid-catalyzed water-mediated rearrangement of 2-furylcarbinols into 4-hydroxycyclopentenones. These motifs are core components of several pharmacologically active compounds and precursors of many natural products. The main features of this reaction are the simple experimental conditions, the stereochemical outcome and the generality of the procedure. Consequently, a re-emergence of this reaction has been seen recently, including developments of the Piancatelli rearrangement with some interesting inter-and intramolecular variants. This review will mainly focus on the general aspects of the reaction along with its more recent applications.
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