期刊
MOLECULES
卷 17, 期 6, 页码 7284-7293出版社
MDPI
DOI: 10.3390/molecules17067284
关键词
Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid
We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 mu g/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 mu g/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
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