期刊
MOLECULES
卷 17, 期 9, 页码 10094-10107出版社
MDPI
DOI: 10.3390/molecules170910094
关键词
microparticles; pomegranate; antifungal activity; Candida albicans
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Financiadora de Estudos e Projetos (FINEP)
- Capacitacao e Aperfeicoamento de Pessoal de Nivel Superior, (Capes)
- Fundacao Araucaria
- Programa de Pos-graduacao em Ciencias Farmaceuticas da Universidade Estadual de Maringa
Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 mu m and 2.80 mu m, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据