期刊
MOLECULES
卷 17, 期 8, 页码 9443-9450出版社
MDPI AG
DOI: 10.3390/molecules17089443
关键词
Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase
资金
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium [10120022]
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
- National Science Council, Taiwan [NSC 101-2325-B-291-001, 100-2325-B-291-001, 101-2320-B-291-001-MY3, 98-2320-B-291-001-MY3]
A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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