期刊
MOLECULES
卷 17, 期 1, 页码 657-663出版社
MDPI
DOI: 10.3390/molecules17010657
关键词
Derris trifoliate; aerial part; prenylated flavanone; rotenoids; brine shrimp toxicity
资金
- Chinese Academy of Sciences [KZCX2-YW-JC202]
- Guangdong Province Natural Science Foundation [91510301000001]
- NSFC [41176149]
- National Basic Research Program of China (973 Program) [2010CB833800]
- Key Laboratory of Marine Bio-resources Sustainable Utilization, Chinese Academy of Sciences [LMB091004]
- Hunan Province Education Bureau [10A071]
A new flavanone, 4',5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)-flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol, 7a-O-methylelliptonol, 5,7,3',4'-tetra-hydroxy- 6,8-diprenylisoflavone, daidzein and 4'-hydroxy-7-methoxyflavanone. 7a-O-Methylelliptonol was isolated for the first time from the genus Derris. Their structures were characterized on the basis of spectral data. Eight of the isolated compounds were found to be significantly toxic to brine shrimp (LC50 range 0.06-9.95 mu g/mL). The new compound showed weak toxicity (LC50 = 211.31 mu g/mL).
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