期刊
MOLECULES
卷 17, 期 10, 页码 11456-11468出版社
MDPI
DOI: 10.3390/molecules171011456
关键词
thienyl derivatives; T98G gliomas; HEK cells
资金
- Kwangwoon University
- SRC program of National Research Foundation of Korea [20100029418]
- New & Renewable Energy of the Korea Institute of Energy Technology Evaluation and Planning (KETEP)
- Korea government Ministry of Knowledge Economy [96002011003]
- Ministry of Knowledge Economy (MKE), Korea
Di(3-thienyl)methanol (2) and di(3-thienyl)methane (3) have been synthesized and screened against the T98G (brain cancer) cell line. Treatment induced cell death (MTT and macro-colony assay), growth inhibition, cytogenetic damage (micronuclei formation), were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK (normal) cell lines. At higher concentrations (>20 mu g/mL) the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations.
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