期刊
MOLECULES
卷 17, 期 4, 页码 4219-4224出版社
MDPI AG
DOI: 10.3390/molecules17044219
关键词
Cephalosporium sp.AL031 fungus; isobenzofuranone; antioxidant activity
资金
- Chinese Ministry of Education [209116]
- Yunnan Social Development Sci-Tech Plan [2009CD100]
- Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province (IRTSTYN)
- Green Chemistry and Functional Materials Research for Yunnan Innovation Team [2011HC008]
Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-4 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 mu M by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
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