期刊
MOLECULES
卷 17, 期 11, 页码 12704-12717出版社
MDPI AG
DOI: 10.3390/molecules171112704
关键词
dispirooxindole; three-component reaction; 1,3-dipolar cycloaddition; azomethine ylide
资金
- Natural Science Foundation of China [81072577, 81102376, 21072144]
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions [10KJA150049]
- Priority Academic Project Development of Jiangsu Higher Education Institutions
- Key Laboratory of Organic Synthesis of Jiangsu Province [KJS0812]
- National S&T Major Special Project on Major New Drug Innovation [2012ZX093101002-001-017]
A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an alpha-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
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