期刊
MOLECULES
卷 17, 期 10, 页码 12378-12392出版社
MDPI
DOI: 10.3390/molecules171012378
关键词
phosphoramidite; cholesterol; solid phase synthesis; anti-HIV G-rich oligonucleotides
资金
- MIUR (PRIN) [2009J54YAP_002]
- AIRC, Italian Association for Cancer Research [11947]
A novel phosphoramidite derivative of cholesterol, with an ether-linked hexaethylene glycol (HEG) spacer arm, has been obtained through simple and reproducible solid phase modified oligonucleotide synthesis manipulations. This building block and the known phosphoramidite derivative of 3 beta-(2-hydroxyethoxy) cholesterol have been exploited in standard oligonucleotide synthesis protocols for the preparation of 5'-conjugates of the G-quadruplex-forming (5)'TGGGAG(3)' oligomer, known as the Hotoda's sequence, to produce new potential anti-HIV agents.
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