期刊
MOLECULES
卷 17, 期 6, 页码 7083-7092出版社
MDPI
DOI: 10.3390/molecules17067083
关键词
insulin resistance; NF-kappa B; PTP1B; Astragalus polysaccharide
资金
- Ministry of Science and Technology of the People's Republic of China [2006BAD27B01]
We investigated the effects of Astragalus polysaccharide (APS) on palmitate-induced insulin resistance in C2C12 skeletal muscle myotubes. Palmitate-reduced glucose uptake was restored by APS. APS prevented palmitate-induced C2C12 myotubes from impaired insulin signaling by inhibiting Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1) and increasing Ser473 phosphorylation of Akt. Moreover, the increases in protein-tyrosine phosphatase-1B (PTP1B) protein level and NF-kappa B activation associated with palmitate treatment were also prevented by APS. However the treatment with APS didn't change AMP-activated protein kinase (AMPK) activation in palmitate-induced myotubes. The results of the present study suggest that Astragalus polysaccharide inhibits palmitate-induced insulin resistance in C2C12 myotubes by inhibiting expression of PTP1B and regulating NF-kappa B but not AMPK pathway.
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