期刊
MOLECULES
卷 16, 期 11, 页码 9129-9141出版社
MDPI
DOI: 10.3390/molecules16119129
关键词
sulfone; oxadiazole; antifungal activity
资金
- National Natural Science Foundation of China [20962005, 20762002]
- National Key Technology RD Program [2011BAE06B05-6, 2011BAE06B02-14, 2011BAE06B02-09]
- S&T Program of Guizhou Province [[2011]3016]
A series of new sulfone compounds containing 1,3,4-oxadiazole moieties were synthesized. The structures of these compounds were confirmed by spectroscopic data (IR, H-1- and C-13-NMR) and elemental analyses. Antifungal tests indicated that all the title compounds exhibited good antifungal activities against eight kinds of plant pathogenic fungi, and some showed superiority over the commercial fungicide hymexazol. Among them, compounds 5d, 5e, 5f, and 5i showed prominent activity against B. cinerea, with determined EC50 values of 5.21 mu g/mL, 8.25 mu g/mL, 8.03 mu g/mL, and 21.00 mu g/mL, respectively. The present work demonstrates that sulfone derivatives such as 5d containing a 1,3,4-oxadiazole moiety can be used as possible lead compounds for the development of potential agrochemicals.
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