期刊
MOLECULES
卷 16, 期 5, 页码 3519-3529出版社
MDPI
DOI: 10.3390/molecules16053519
关键词
Streptomyces; gombapyrone; alpha-pyrone; polyene
资金
- Korea Institute of Science and Technology [2Z03401]
Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be alpha-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.
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