期刊
MOLECULES
卷 16, 期 5, 页码 4140-4164出版社
MDPI
DOI: 10.3390/molecules16054140
关键词
5-aminolevulinic acid; photodynamic therapy; cancer; laser; singlet oxygen
资金
- Ministry of Science and Higher education [N N401 037138]
- European Regional Development Fund [POIG.01.01.02-00-008/08]
- Foundation for Polish Science
- EU
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme. Conversion of PpIX to its downstream substrates requires the activity of a rate-limiting enzyme ferrochelatase. When ALA is administered externally the abundantly produced PpIX cannot be quickly converted to its final product - heme by ferrochelatase and therefore accumulates within cells. Since PpIX is a potent photosensitizer this metabolic pathway can be exploited in photodynamic therapy (PDT). This is an already approved therapeutic strategy making ALA one of the most successful prodrugs used in cancer treatment.
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