期刊
MOLECULES
卷 15, 期 11, 页码 8488-8500出版社
MDPI
DOI: 10.3390/molecules15118488
关键词
eigallocatechin-3-gallate; vascular endothelial cells; vascular smooth muscle cells; proliferation; migration
资金
- Ministry for Health, Welfare & Family Affairs, Republic of Korea [A085136]
- Ministry of Knowledge Economy, Republic of Korea [K0006028]
- Ministry of Education, Science and Technology [2010-0002954]
- National Research Foundation of Korea [2010-0002954] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In order to prevent restenosis after angioplasty or stenting, one of the most popular targets is suppression of the abnormal growth and excess migration of vascular smooth muscle cells (VSMCs) with drugs. However, the drugs also adversely affect vascular endothelial cells (VECs), leading to the induction of late thrombosis. We have investigated the effect of epigallocatechin-3-gallate (EGCG) on the proliferation and migration of VECs and VSMCs. Both cells showed dose-dependent decrease of viability in response to EGCG while they have different IC50 values of EGCG (VECs, 150 mu M and VSMCs, 1050 mu M). Incubating both cells with EGCG resulted in significant reduction in cell proliferation irrespective of cell type. The proliferation of VECs were greater affected than that of VSMCs at the same concentrations of EGCG. EGCG exerted differential migration-inhibitory activity in VECs vs. VSMCs. The migration of VECs was not attenuated by 200 mu M EGCG, but that of VSMCs was significantly inhibited at the same concentration of EGCG. It is suggested that that EGCG can be effectively used as an efficient drug for vascular diseases or stents due to its selective activity, completely suppressing the proliferation and migration of VSMCs, but not adversely affecting VECs migration in blood vessels.
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