4.6 Review

Potential of the Dietary Antioxidants Resveratrol and Curcumin in Prevention and Treatment of Hematologic Malignancies

期刊

MOLECULES
卷 15, 期 10, 页码 7035-7074

出版社

MDPI
DOI: 10.3390/molecules15107035

关键词

dietary polyphenolic antioxidants; resveratrol; curcumin and derivatives; leukemia

资金

  1. Fonds National de la Recherche Luxembourg
  2. Recherche Cancer et Sang foundation
  3. Recherches Scientifiques Luxembourg asbl
  4. Een Haerz fir Kriibskrank Kanner association
  5. Action Lions Vaincre le Cancer Luxembourg
  6. Televie Luxembourg
  7. Foundation for Scientific Cooperation
  8. University of Saarland
  9. Ministry of Economics and Science of Saarland
  10. Deutsche Forschungsgemeinschaft (DFG) [JA1741/2-1, HE3553/2-1]
  11. European Union [215009]
  12. Fonds National de la Recherche - Luxembourg

向作者/读者索取更多资源

Despite considerable improvements in the tolerance and efficacy of novel chemotherapeutic agents, the mortality of hematological malignancies is still high due to therapy relapse, which is associated with bad prognosis. Dietary polyphenolic compounds are of growing interest as an alternative approach, especially in cancer treatment, as they have been proven to be safe and display strong antioxidant properties. Here, we provide evidence that both resveratrol and curcumin possess huge potential for application as both chemopreventive agents and anticancer drugs and might represent promising candidates for future treatment of leukemia. Both polyphenols are currently being tested in clinical trials. We describe the underlying mechanisms, but also focus on possible limitations and how they might be overcome in future clinical use - either by chemically synthesized derivatives or special formulations that improve bioavailability and pharmacokinetics.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据