期刊
MOLECULES
卷 15, 期 12, 页码 9205-9213出版社
MDPI
DOI: 10.3390/molecules15129205
关键词
Esenbeckia leiocarpa; Rutaceae; alkaloids; acetylcholinesterase inhibitors
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/02176-7]
- CNPq
- PRODOC/CAPES of Instituto de Botanica of Sao Paulo, Brazil
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/02176-7] Funding Source: FAPESP
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC50 = 2.5 mu M), similar to that of the reference compound galanthamine (IC50 = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
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