期刊
MOLECULES
卷 15, 期 8, 页码 5768-5781出版社
MDPI
DOI: 10.3390/molecules15085768
关键词
Click chemistry; CuAAC; Boronic acids
资金
- National Institutes of Health [GM086925, GM084933]
- Georgia State University, Georgia Cancer Coalition, and Georgia Research Alliance
Boronic acids have been widely used in a wide range of organic reactions, in the preparation of sensors for carbohydrates, and as potential pharmaceutical agents. With the growing importance of click reactions, inevitably they are also applied to the synthesis of compounds containing the boronic acid moiety. However, such applications have unique problems. Chief among them is the issue of copper-mediated boronic acid degradation in copper-assisted [2,3]-cycloadditions involving an alkyne and an azido compound as the starting materials. This review summarizes recent developments, analyzes potential issues, and discusses known as well as possible solutions.
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