期刊
MOLECULES
卷 15, 期 9, 页码 6019-6034出版社
MDPI
DOI: 10.3390/molecules15096019
关键词
type III secretion; Suzuki coupling; Grignard addition
资金
- Swedish Research Council
- Carl Trygger Foundation
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
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