期刊
MOLECULES
卷 15, 期 4, 页码 2686-2718出版社
MDPI
DOI: 10.3390/molecules15042686
关键词
iodine-124; positron emission tomography (PET); molecular imaging
The use of radiopharmaceuticals for molecular imaging of biochemical and physiological processes in vivo has evolved into an important diagnostic tool in modern nuclear medicine and medical research. Positron emission tomography (PET) is currently the most sophisticated molecular imaging methodology, mainly due to the unrivalled high sensitivity which allows for the studying of biochemistry in vivo on the molecular level. The most frequently used radionuclides for PET have relatively short half-lives (e. g. C-11: 20.4 min; F-18: 109.8 min) which may limit both the synthesis procedures and the time frame of PET studies. Iodine-124 (I-124, t(1/2) = 4.2 d) is an alternative long-lived PET radionuclide attracting increasing interest for long term clinical and small animal PET studies. The present review gives a survey on the use of I-124 as promising PET radionuclide for molecular imaging. The first part describes the production of I-124. The second part covers basic radiochemistry with I-124 focused on the synthesis of I-124-labeled compounds for molecular imaging purposes. The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter I-124 in the field of organic PET chemistry and molecular imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据