期刊
MOLECULES
卷 15, 期 4, 页码 2439-2452出版社
MDPI
DOI: 10.3390/molecules15042439
关键词
verapamil hydrochloride; thermal analysis; degradation kinetics; characterization
资金
- FAPES
- CNPq
- FAPEMIG
Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 180 degrees C and melts at 146 degrees C, followed by total degradation. The drug is compatible with all the excipients evaluated. The drug showed degradation when subjected to oxidizing conditions, suggesting that the degradation product is 3,4-dimethoxybenzoic acid derived from alkyl side chain oxidation. Verapamil hydrochloride does not present the phenomenon of polymorphism under the conditions evaluated. Assessing the drug degradation kinetics, the drug had a shelf life (t(90)) of 56.7 years and a pharmaceutical formulation showed t(90) of 6.8 years showing their high stability.
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