期刊
MOLECULES
卷 15, 期 7, 页码 4961-4983出版社
MDPI AG
DOI: 10.3390/molecules15074961
关键词
Distributed Drug Discovery (D3); fundamental peptide scaffold; biomimetics; solid-phase organic synthesis; combinatorial chemistry
资金
- National Institutes of Health [R01 GM028193]
- National Science Foundation [MRI CHE-0619254]
- Camille and Henry Dreyfus Foundation
- Central Indiana Community Foundation
- Polish Ministry of Science and Higher Education (MNiSW) [N N405 378437]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0821661] Funding Source: National Science Foundation
Amino acids are Nature's combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the variety of substituted biomimetic molecules available to successfully implement the Distributed Drug Discovery (D3) project. In a single solid-phase sequence, compatible with basic amine substituents, three-point variation is performed at the amino acid alpha-carbon and the amino and carboxyl functionalities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据