期刊
MOLECULES
卷 14, 期 7, 页码 2337-2344出版社
MDPI
DOI: 10.3390/molecules14072337
关键词
selenoprotein; methionine sulfoxide; oxidative stress; antioxidants; posttranslational modification
Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R-and the S-forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA(-)/(-)), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA(-)/(-) ice are presented and discussed.
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