Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives

The aim of this study was to identify new compounds active against Plasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline2- carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were synthesized and evaluated for antimalarial activity. Eight of them showed an IC50 < 1 mu M against the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 mu M) and good selectivity (SI= 10.35), thereby becoming a new lead-compound.