期刊
MOLECULAR THERAPY
卷 19, 期 3, 页码 536-546出版社
CELL PRESS
DOI: 10.1038/mt.2010.267
关键词
-
资金
- NIH [P01 HL78810]
Using adoptive transfer models we determined that an adeno-associated viral vector of serotype 2 (AAV2) induces in mice proliferation of CD8+ T cells that recognize an epitope within the viral capsid. Proliferation to an endogenous epitope within viral protein (VP) 3 could be observed for at least 3 weeks while a foreign epitope placed at multiple copies within VP2 elicited CD8+ T cell expansion for at least 10 weeks. These data show that capsid antigens of AAV2 degrade slowly over a period of weeks and during this period provide targets to CD8+ T cells.
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