期刊
MOLECULAR THERAPY
卷 17, 期 12, 页码 2041-2048出版社
CELL PRESS
DOI: 10.1038/mt.2009.218
关键词
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资金
- Mayo Clinic [P50 CA 091956]
Prostate cancer cells overexpress the measles virus (MV) receptor CD46. Herein, we evaluated the antitumor activity of an oncolytic derivative of the MV Edmonston (MV-Edm) vaccine strain engineered to express the human sodium iodide symporter (NIS; MV-NIS virus). MV-NIS showed significant cytopathic effect (CPE) against prostate cancer cell lines in vitro. Infected cells effectively concentrated radioiodide isotopes as measured in vitro by Iodide-125 (I-125) uptake assays. Virus localization and spread in vivo could be effectively followed by imaging of I-123 uptake. In vivo administration of MV-NIS either locally or systemically (total dose of 9 x 10(6) TCID50) resulted in significant tumor regression (P < 0.05) and prolongation of survival (P < 0.01). Administration of I'll further enhanced the antitumor effect of MV-NIS virotherapy (P < 0.05). In conclusion, MV-NIS is an oncolytic vector with significant antitumor activity against prostate cancer, which can be further enhanced by I-131 administration. The NIS transgene allows viral localization and monitoring by noninvasive imaging which can facilitate dose optimization in a clinical setting.
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