期刊
MOLECULAR SYSTEMS BIOLOGY
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/msb.2011.62
关键词
half-life; operational strategy; pre-mRNA; transcriptional response
资金
- Leir Charitable Foundation
- Weizmann-Mario Negri
- MD Moross Institute for Cancer Research, Arresto Biosciences
- European Commission
- Dr Miriam and Sheldon Adelson Medical Research Foundation
- Kekst Family Institute for Medical Genetics
- Kirk Center for Childhood Cancer and Immunological Disorders
- Bennett-Pritzker Endowment Fund
- Marvelle Koffler Program for Breast Cancer Research
- German Research Foundation (DIP)
- National Cancer Institute [CA72981]
- Flight Attendants Medical Research Institute (FAMRI)
- Linda and Michael Jacobs Charitable Trust
Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide measurements demonstrate that genes with similar mRNA profiles often exhibit marked differences in the amplitude and onset of their production rate. The latter is characterized by a large dynamic range, with a group of genes exhibiting an unexpectedly strong transient production overshoot, thereby accelerating their induction and, when combined with time-dependent degradation, shaping transient responses with precise timing and amplitude. Molecular Systems Biology 7: 529; published online 13 September 2011; doi:10.1038/msb.2011.62
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