期刊
MOLECULAR SYSTEMS BIOLOGY
卷 10, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/msb.134859
关键词
DNA replication timing; computational model; DNase hypersensitivity; systems analysis
资金
- NIH, National Cancer Institute, Center for Cancer Research
- NIH [SC1CA1 138180]
A mechanistic model predicts cell lineage-specific DNA replication timing based on the location of DNase-hypersensitivity data alone. With essentially no parameters to adjust for different cell types, the model is truly predictive even for cells where timing data are not available.image
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