期刊
MOLECULAR SYSTEMS BIOLOGY
卷 9, 期 -, 页码 -出版社
WILEY
DOI: 10.1038/msb.2013.40
关键词
Arabidopsis; development; root apical meristem; signaling gradient
资金
- NSF [DBI-0519984]
- NIH [R01-GM078270, R01-GM086632, GM43644]
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation
- EMBO (LTF)
- Vaadia-BARD [FI-431-10]
- Research Foundation of Flanders
In plants, changes in local auxin concentrations can trigger a range of developmental processes as distinct tissues respond differently to the same auxin stimulus. However, little is known about how auxin is interpreted by individual cell types. We performed a transcriptomic analysis of responses to auxin within four distinct tissues of the Arabidopsis thaliana root and demonstrate that different cell types show competence for discrete responses. The majority of auxin-responsive genes displayed a spatial bias in their induction or repression. The novel data set was used to examine how auxin influences tissue-specific transcriptional regulation of cell-identity markers. Additionally, the data were used in combination with spatial expression maps of the root to plot a transcriptomic auxin-response gradient across the apical and basal meristem. The readout revealed a strong correlation for thousands of genes between the relative response to auxin and expression along the longitudinal axis of the root. This data set and comparative analysis provide a transcriptome-level spatial breakdown of the response to auxin within an organ where this hormone mediates many aspects of development.
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