期刊
MOLECULAR SYSTEMS BIOLOGY
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/msb.2010.46
关键词
adipose tissue; endocannabinoids; gut microbiota; lipopolysaccharide (LPS); obesity
资金
- Fonds speciaux de recherches, UCL, Belgium (FSR)
- Fonds de la recherche scientifique medicale, Belgium (FRSM)
- Danone Institute
- SFD (Societe francophone du Diabete, France)
- Charcot Foundation (Belgium)
- Swedish Research Council
- Swedish Foundation for Strategic Research
- Vastra Gotalandsregionen
- Belgian National Fund for Scientific Research (FNRS) [FRFC 2.4555.08]
Obesity is characterised by altered gut microbiota, low-grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed. Here, we report that gut microbiota modulate the intestinal eCB system tone, which in turn regulates gut permeability and plasma lipopolysaccharide (LPS) levels. The impact of the increased plasma LPS levels and eCB system tone found in obesity on adipose tissue metabolism (e. g. differentiation and lipogenesis) remains unknown. By interfering with the eCB system using CB1 agonist and antagonist in lean and obese mouse models, we found that the eCB system controls gut permeability and adipogenesis. We also show that LPS acts as a master switch to control adipose tissue metabolism both in vivo and ex vivo by blocking cannabinoid-driven adipogenesis. These data indicate that gut microbiota determine adipose tissue physiology through LPS-eCB system regulatory loops and may have critical functions in adipose tissue plasticity during obesity. Molecular Systems Biology 6: 392; published online 27 July 2010; doi:10.1038/msb.2010.46 Subject Categories: molecular biology of disease
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