期刊
MOLECULAR SYSTEMS BIOLOGY
卷 6, 期 -, 页码 -出版社
WILEY
DOI: 10.1038/msb.2010.23
关键词
C. elegans; gene regulatory network; metabolism; nuclear hormone receptor; transcription factor
资金
- NIH [DK068429, DK071713, CA020535]
- National Institute of Diabetes and Digestive and Kidney Diseases [5 P30 DK32520]
- UMass DERC [DK32520]
- American Heart Association
- American Federation for Aging Research
- NATIONAL CANCER INSTITUTE [R01CA020535, R37CA020535] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068429, R21DK071713, P30DK032520] Funding Source: NIH RePORTER
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues. In this study, we report the first experimentally mapped metazoan GRN of Caenorhabditis elegans metabolic genes. This network is enriched for nuclear hormone receptors (NHRs). The NHR family has greatly expanded in nematodes: humans have 48 NHRs, but C. elegans has 284, most of which are uncharacterized. We find that the C. elegans metabolic GRN is highly modular and that two GRN modules predominantly consist of NHRs. Network modularity has been proposed to facilitate a rapid response to different cues. As NHRs are metabolic sensors that are poised to respond to ligands, this suggests that C. elegans GRNs evolved to enable rapid and adaptive responses to different cues by a concurrence of NHR family expansion and modular GRN wiring. Molecular Systems Biology 6: 367; published online 11 May 2010; doi: 10.1038/msb.2010.23
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