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ML Blinov et al.
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V Grimm et al.
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NM Borisov et al.
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ZG Jin et al.
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A Montagner et al.
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DD Sarbassov et al.
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S Lehr et al.
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MP Chong et al.
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S Sato et al.
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C Wellbrock et al.
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S Mangan et al.
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PC Chan et al.
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YM Agazie et al.
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H Resat et al.
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E Asante-Appiah et al.
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S Gogg et al.
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JM Cunnick et al.
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A Yart et al.
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LP Weng et al.
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MF Crouch et al.
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A Chaudhary et al.
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BJ Goldstein et al.
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