期刊
MOLECULAR REPRODUCTION AND DEVELOPMENT
卷 78, 期 10-11, 页码 704-707出版社
WILEY-BLACKWELL
DOI: 10.1002/mrd.21343
关键词
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资金
- Ministry of Education, Science and Culture, Japan
This short review updates the maturation-inducing hormonal signaling in starfish oocytes. In this system, the activation of cyclin B-Cdc2 kinase (Cdk1) that leads to meiotic resumption does not require new protein synthesis. The key intracellular mediator after hormonal stimulation by 1-methyladenine is the protein kinase Akt/PKB, which in turn directly downregulates Myt1 and upregulates Cdc25 toward the activation of cyclin B-Cdc2. Mitotic kinases including Aurora, Plk1 and Greatwall are activated downstream of cyclin B-Cdc2. The starfish oocyte thus provides a simple model system for the study of meiotic resumption.
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