期刊
MOLECULAR PSYCHIATRY
卷 20, 期 9, 页码 1101-1107出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2014.140
关键词
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资金
- GDR 'Institut de Recherche en Psychiatrie' [CNRS-3557]
- ERANET-NEURON program (AUSZ_EUCan)
- Programme Hospitalier de Recherche Clinique (PHRC Multimodhal)
- Pierre Houriez foundation
- Pierre Deniker foundation
- NRJ foundation
Hallucinations, and auditory hallucinations (AH) in particular, constitute the most typical and disabling schizophrenia symptoms. Although visual hallucinations (VH) have been largely neglected in psychiatric disorders, a recent review reported a 27% mean prevalence of VH in schizophrenia patients. The pathophysiology underlying VH in schizophrenia remains elusive. Several schizophrenia studies reported a significant effect of age on VH; therefore, we tested the hypothesis that the neurodevelopmental model of schizophrenia may explain VH occurrence. We analyzed cortex sulcation, a marker of brain development, in healthy controls (HCs) and two subgroups of carefully selected schizophrenia patients suffering from hallucinations: patients with only AH (that is, patients who never reported VH) and patients with audio-visual hallucinations (A+VH). Different cortical sulcation and left-right sulcal asymmetry were found between A+VH and AH patients, with decreased sulcation in both A+VH and AH patients in comparison with the HCs. Although a specific association between VH and neurodegenerative mechanisms, for example, in Body-Lewy Dementia or Parkinson's Disease, has previously been reported in the literature, the current study provides the first neuroimaging evidence of an association between VH and neurodevelopmental mechanisms.
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