期刊
MOLECULAR PSYCHIATRY
卷 19, 期 3, 页码 380-384出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2012.191
关键词
cognitive development; Genome-wide complex trait analysis (GCTA); intelligence; twins
资金
- UK Medical Research Council [G0901245]
- US National Institutes of Health [HD044454, HD046167]
- Wellcome Trust [085475/B/08/Z, 085475/Z/08/Z]
- Medical Research Council Research Professorship award [G19/2]
- European Advanced Investigator award [295366]
- Medical Research Council studentship
- Wellcome Trust [085475/B/08/Z] Funding Source: Wellcome Trust
- MRC [G0901245, G0500079, G19/2] Funding Source: UKRI
- Medical Research Council [G9817803B, G0901245, G19/2, G0500079] Funding Source: researchfish
Two genetic findings from twin research have far-reaching implications for understanding individual differences in the development of brain function as indexed by general cognitive ability (g, aka intelligence): (1) The same genes affect g throughout development, even though (2) heritability increases. It is now possible to test these hypotheses using DNA alone. From 1.7 million DNA markers and g scores at ages 7 and 12 on 2875 children, the DNA genetic correlation from age 7 to 12 was 0.73, highly similar to the genetic correlation of 0.75 estimated from 6702 pairs of twins from the same sample. DNA-estimated heritabilities increased from 0.26 at age 7 to 0.45 at age 12; twin-estimated heritabilities also increased from 0.35 to 0.48. These DNA results confirm the results of twin studies indicating strong genetic stability but increasing heritability for g, despite mean changes in brain structure and function from childhood to adolescence.
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