期刊
MOLECULAR PSYCHIATRY
卷 17, 期 9, 页码 867-874出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2012.68
关键词
environmental exposure; epidemiology; geocoding; statistical genetics; twin study; visualization
资金
- UK Medical Research Council (MRC) [G0500079]
- US National Institutes of Health (NIH) [HD44454]
- Wellcome Trust [WT088984]
- British Academy
- MRC [G19/2, G0500079] Funding Source: UKRI
- Medical Research Council [G9817803B, G0500079, G19/2] Funding Source: researchfish
Twin studies allow us to estimate the relative contributions of nature and nurture to human phenotypes by comparing the resemblance of identical and fraternal twins. Variation in complex traits is a balance of genetic and environmental influences; these influences are typically estimated at a population level. However, what if the balance of nature and nurture varies depending on where we grow up? Here we use statistical and visual analysis of geocoded data from over 6700 families to show that genetic and environmental contributions to 45 childhood cognitive and behavioral phenotypes vary geographically in the United Kingdom. This has implications for detecting environmental exposures that may interact with the genetic influences on complex traits, and for the statistical power of samples recruited for genetic association studies. More broadly, our experience demonstrates the potential for collaborative exploratory visualization to act as a lingua franca for large-scale interdisciplinary research.
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