期刊
MOLECULAR PSYCHIATRY
卷 17, 期 11, 页码 1056-1076出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2011.147
关键词
Alzheimer's disease (AD); brain; dementia; mild cognitive impairment; neuropathology; vascular dementia
资金
- NIHR Peninsula Collaboration for Leadership in Applied Health Research and Care (PenCLAHRC)
- Joint European Post-Doctoral Programme: The European Research Area in Ageing (ERA-AGE) Network FLARE Programme
- Medical Research Council [G9901400, G0400077, G0701539, MC_U105292687] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10084] Funding Source: researchfish
- MRC [MC_U105292687, G9901400, G0701539, G0400077] Funding Source: UKRI
Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects an intermediate state between no cognitive impairment and dementia is not clear. Identifying which biological events occur at the earliest stage of progressive disease and which are secondary to the neuropathological process is important for understating pathological pathways and for targeted disease prevention. Many studies have now reported on the neurobiology of this intermediate stage. In this systematic review, we synthesize current evidence on the neuropathological profile of MCI. A total of 162 studies were identified with varied definition of MCI, settings ranging from population to specialist clinics and a wide range of objectives. From these studies, it is clear that MCI is neuropathologically complex and cannot be understood within a single framework. Pathological changes identified include plaque and tangle formation, vascular pathologies, neurochemical deficits, cellular injury, inflammation, oxidative stress, mitochondrial changes, changes in genomic activity, synaptic dysfunction, disturbed protein metabolism and disrupted metabolic homeostasis. Determining which factors primarily drive neurodegeneration and dementia and which are secondary features of disease progression still requires further research. Standardization of the definition of MCI and reporting of pathology would greatly assist in building an integrated picture of the clinical and neuropathological profile of MCI. Molecular Psychiatry (2012) 17, 1056-1076; doi: 10.1038/mp.2011.147; published online 6 December 2011
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