期刊
MOLECULAR PSYCHIATRY
卷 16, 期 11, 页码 1130-1138出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2010.123
关键词
Alzheimer's disease; imaging-genetics; quantitative trait
资金
- EU FP6 program as part of InnoMed
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- NIH [P30 AG010129, K01 AG030514]
- Dana Foundation
- Alzheimers Research UK [ART-PPG2008A-2, ART-RF2007-3] Funding Source: researchfish
- Medical Research Council [G9817803B] Funding Source: researchfish
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with considerable evidence suggesting an initiation of disease in the entorhinal cortex and hippocampus and spreading thereafter to the rest of the brain. In this study, we combine genetics and imaging data obtained from the Alzheimer's Disease Neuroimaging Initiative and the AddNeuroMed study. To identify genetic susceptibility loci for AD, we conducted a genome-wide study of atrophy in regions associated with neurodegeneration in this condition. We identified one single-nucleotide polymorphism (SNP) with a disease-specific effect associated with entorhinal cortical volume in an intron of the ZNF292 gene (rs1925690; P-value = 2.6 x 10(-8); corrected P-value for equivalent number of independent quantitative traits = 7.7 x 10(-8)) and an intergenic SNP, flanking the ARPP-21 gene, with an overall effect on entorhinal cortical thickness (rs11129640; P-value = 5.6 x 10(-8); corrected P-value = 1.7 x 10(-7)). Gene-wide scoring also highlighted PICALM as the most significant gene associated with entorhinal cortical thickness (P-value = 6.7 x 10(-6)). Molecular Psychiatry (2011) 16, 1130-1138; doi:10.1038/mp.2010.123; published online 30 November 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据