期刊
MOLECULAR PSYCHIATRY
卷 15, 期 1, 页码 18-22出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2009.123
关键词
gene-environment interactions; serotonin transporter; depression; stressful life events; adversity; adolescence
资金
- Medical Research Council [G9817803B] Funding Source: researchfish
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression. Molecular Psychiatry (2010) 15, 18-22; doi: 10.1038/mp.2009.123
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