期刊
MOLECULAR PSYCHIATRY
卷 15, 期 1, 页码 53-63出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2008.94
关键词
epidemiology; obsessive behavior; compulsive behavior; obsessive-compulsive disorder; National Comorbidity Survey Replication
资金
- National Institute of Mental Health (NIMH) Career Development Award [K01-MH076162, U01-MH60220, R01 MH070884]
- Medical Research Council of South Africa
- National Institute on Drug Abuse (NIDA)
- Substance Abuse and Mental Health Services Administration (SAMHSA)
- Robert Wood Johnson Foundation (RWJF) [044780]
- John W Alden Trust
- John D and Catherine T MacArthur Foundation
- Pfizer Foundation
- US Public Health Service [R13-MH066849, R01-MH069864, R01 DA016558]
- Fogarty International Center (FIRCA) [R03-TW006481]
- Pan American Health Organization
- Eli Lilly and Company
- Ortho-McNeil Pharmaceutical Inc.
- Glaxo SmithKline and Bristol-Myers Squibb
- FOGARTY INTERNATIONAL CENTER [R03TW006481] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [U01MH060220, U13MH066849, R01MH070884, R13MH066849, R01MH069864, K01MH076162] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA016558, K05DA015799] Funding Source: NIH RePORTER
Despite significant advances in the study of obsessive-compulsive disorder (OCD), important questions remain about the disorder's public health significance, appropriate diagnostic classification, and clinical heterogeneity. These issues were explored using data from the National Comorbidity Survey Replication, a nationally representative survey of US adults. A subsample of 2073 respondents was assessed for lifetime Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV) OCD. More than one quarter of respondents reported experiencing obsessions or compulsions at some time in their lives. While conditional probability of OCD was strongly associated with the number of obsessions and compulsions reported, only small proportions of respondents met full DSM-IV criteria for lifetime (2.3%) or 12-month (1.2%) OCD. OCD is associated with substantial comorbidity, not only with anxiety and mood disorders but also with impulse-control and substance use disorders. Severity of OCD, assessed by an adapted version of the Yale-Brown Obsessive Compulsive Scale, is associated with poor insight, high comorbidity, high role impairment, and high probability of seeking treatment. The high prevalence of subthreshold OCD symptoms may help explain past inconsistencies in prevalence estimates across surveys and suggests that the public health burden of OCD may be greater than its low prevalence implies. Evidence of a preponderance of early onset cases in men, high comorbidity with a wide range of disorders, and reliable associations between disorder severity and key outcomes may have implications for how OCD is classified in DSM-V. Molecular Psychiatry (2010) 15, 53-63; doi: 10.1038/mp.2008.94; published online 26 August 2008
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据