期刊
MOLECULAR PSYCHIATRY
卷 14, 期 10, 页码 954-958出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2008.112
关键词
stress; trauma; development; oxytocin; anxiety; depression
资金
- NCRR NIH HHS [RR00165, M01-RR00039] Funding Source: Medline
- NIMH NIH HHS [MH-64692, MH-56539, MH-58922, P50 MH058922] Funding Source: Medline
Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, maternal behavior and trust, as well as protection against stress and anxiety. We therefore examined central nervous system OT activity after early-life adversity in adult women. We measured OT concentrations in cerebrospinal fluid (CSF) collected from 22 medically healthy women, aged 18-45 years, categorized into those with none-mild versus those with moderate-severe exposure to various forms of childhood abuse or neglect. Exposure to maltreatment was associated with decreased CSF OT concentrations. A particularly strong effect was identified for emotional abuse. There were inverse associations between CSF OT concentrations and the number of exposure categories, the severity and duration of the abuse and current anxiety ratings. If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity. Molecular Psychiatry (2009) 14, 954-958; doi:10.1038/mp.2008.112; published online 28 October 2008
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